Safety and efficacy have not been established. Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of loteprednol and tobramycin eye drops in the elderly.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription over-the-counter [OTC] medicine. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur.
Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:. Your eye doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to.
This medicine is not for long-term use. To help clear up your eye infection completely, keep using this medicine for the full time of treatment, even if your eye feels better. If you normally wear soft contact lenses, remove them while you are using this medicine. Talk to your eye doctor about this if you have questions. The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine.
If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine.
Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. If you miss a dose of this medicine, take it as soon as possible.
However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.
Keep from freezing. If you will be using this medicine for more than a few weeks, your eye doctor will check your eyes at regular visits to make sure it is working properly and is not causing unwanted effects. If your symptoms do not improve within a few days or if they become worse, check with your eye doctor. When new therapeutic agents such as Zylet become available, we must examine the research on these agents so we understand what we are prescribing and when to best utilize these new medications.
A randomized, double-masked, placebo-controlled, multicenter comparison of loteprednol etabonate ophthalmic suspension, 0. Am J Ophthalmol Sep; 3 : Long-term safety of loteprednol etabonate 0. Eye Contact Lens Jan;30 1 Intraocular pressure response to loteprednol etabonate in known steroid responders. J Ocul Pharmacol Summer;9 2 Effect of corticosteroids on cataract formation.
Arch Ophthalmol Oct; 98 10 Wilhelmus KR. Indecision about corticosteroids for bacterial keratitis: an evidence-based update. Ophthalmology May; 5 Double-masked, placebo-controlled evaluation of loteprednol etabonate 0. J Cataract Refract Surg Nov; 24 11 The effectiveness of tobramycin and Ocuflox in a prophylaxis model of Staphlococcus keratitis. Curr Eye Res Jul;23 1 Evaluation of the AutoMicrobic system for susceptibility testing of aminoglycosides and gram-negative bacilli.
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